Subject: Q:$DES with a lagged zero-order bolus dose
Date: 24 Jun 1998 16:45:53 -0500
Dear NONMEM users:
I am trying to use ADVAN6 to model a zero-order bolus dose with a lag time. I am having difficulty figuring out how to do this. (I know I could do this with ADVAN3 but there are other modeling issues which require the differential equation solver.)
The code I have been using (obviously wrong) is like the following:
$INPUT ID AMT EVID TIME DV=LCON RATE (rate=-2 duration)
$SUBROUTINE ADVAN6 TRANS1 TOL=5
CALLFL=-2 (for lagged dose call to PK)
IF (T.LE.DOSTIM) Z=1
I can't seem to figure out how to code the differential equations? Any advice would be appreciated.
From: firstname.lastname@example.org.EDU (ABoeckmann)
Subject: Re: Q:$DES with a lagged zero-order bolus dose
Date: 29 Jun 1998 18:30:39 -0400
With ADVAN6, dosing is handled the same as with ADVAN3 (or any other ADVAN routine). Include a dose record with the AMT and the RATE data items, setting RATE to -2. This indicates that D1 will be modelled in $PK, as was done. In the $DES block, code only the compartmental kinetics.
PREDPP itself adds an extra term to DADT(1) giving the total rate of infusion into the compartment (in this case, AMT/D1) when appropriate:
starting when time = ALAG1, and ending when the given AMT has been entered into the system.
The $DES block should be simply: